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The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer development has increasingly been appreciated. Nov Journal of Medical Genetics. In oncology, the expanding use of multi-gene panels to explore familial cancer predisposition and tumor genome analysis has led to increased secondary findings discoveries SFs and has given rise to important medical, ethical, and legal issues. Humberto Gomes rated it liked it Feb 16, Both guidelines recommend that all patients with PPGLs should consider genetic testing as part of their management. In the revised American Thyroid Association ATA guidelines for the management of medullary thyroid carcinoma MTC the AF mutation has been reclassified from the highest to high risk level, although no well-defined risk profile for this mutation exists.